Culling inspiration from James P. Moore, Jr.'s tome One Nation Under God: The History of Prayer in America, the feature-length documentary Prayer in America meditates on the religious practice of prayer - an activity exercised by an estimated 80% of all Americans - as it manifests itself in the 21st century United States.

Subtopics include: the heated debate over school prayer, prayer's usefulness to achieve redemption and forgiveness, the impact of prayer on the tide of history, and the unification of prayers on an interfaith leve amid periods of intense crisis.